{"product_id":"vitals-curcumine-slcp-60-capsules","title":"Vitals Curcumin SLCP 60 Capsules","description":"\u003cb\u003eVitals Curcumin SLCP\u003c\/b\u003e\u003cbr\u003eCurcumin is one of the most well-known and widely used herbal preparations. Curcumin is the main active ingredient of turmeric, an aromatic spice from the root of Curcuma longa. Turmeric originates in Indian cuisine, where it is an important component of the famous curry dishes under the names koenjit or yellow root.\r\u003cbr\u003e\r\u003cbr\u003eCurcumin-SLCP™: a technological breakthrough \r\u003cbr\u003e The biggest challenge in developing curcumin preparations with optimal efficacy is overcoming the issues of its absorbability and bioavailability. Curcumin in an 'unprocessed' form is quickly converted into inactive metabolites, such as curcumin-glucuronide, in the intestine and liver after oral intake, which are then rapidly excreted by the body. Verdure Sciences, the producer of Curcumin-SLCP™ from Vitals, has succeeded in solving these problems after years of research and collaboration with the University of California (UCLA). Through their patented technology, they have managed to increase the absorbability of curcumin by 65x and the bioavailability by as much as 285x (compared to standard curcumin preparations consisting of 95% curcumin). This breakthrough was achieved after testing many different formulations for their bioavailability in humans. The most optimal results were obtained with a formulation that is actually inspired by Indian cuisine, where turmeric is mixed with oily components in the preparation of curry pastes. In their curcumin product branded Longvida®, they use so-called Solid Lipid Curcumin Particles, where the curcumin is encapsulated in a fatty particle consisting of three long-chain fatty acids also found in food, namely phosphatidylcholine, stearic acid, and ascorbyl palmitate. \r\u003cbr\u003e\r\u003cbr\u003eHow is Curcumin-SLCP™ absorbed in the body?\r\u003cbr\u003e Normally, curcumin is absorbed in the same way as most other nutrients (such as sugars and amino acids). In the intestinal epithelium, a first enzymatic conversion of biologically active curcumin into curcumin-glucuronide, an inactive metabolite, takes place. Then, curcumin travels through the portal vein blood to the liver, where it is further inactivated and quickly excreted. However, Curcumin-SLCP™ utilizes an alternative route of absorption in the body. Due to the unique way it is surrounded by fats, it is recognized by the body as such and treated in the same way as other long-chain fats in the diet. These are absorbed in the intestinal cells in chylomicrons (transport particles) and transported via the lymphatic system to the bloodstream. Initially, these chylomicrons do not pass through the liver but are transported through the blood to various tissues and organs, where they release their contents on-site, under the influence of a fat-splitting enzyme (lipoprotein lipase). The curcumin in the chylomicron is still in the biologically active form, which is also referred to as 'free' curcumin. In this form, it is released from the chylomicron and absorbed into the tissues and organs where it can exert its effects. Biologically active (free) curcumin itself is a fatty substance and can even cross the blood-brain barrier in this way, unlike the inactive metabolites of curcumin, and provide support to the functioning of the central nervous system. \r\u003cbr\u003e\r\u003cbr\u003eAbsorbability versus bioavailability\r\u003cbr\u003e There is often talk about the absorbability of a certain substance. This refers to the maximum blood concentration (Cmax) that is reached at a certain time after oral intake of a nutrient. Absorbability is part of bioavailability, but it certainly does not tell the whole story. A nutrient can be very well absorbed and quickly reach a very high blood concentration, but then be broken down and removed from the body very quickly without having had enough time to be effective. It is important to also look at the development over time regarding blood concentration and not just at the moment when the maximum blood concentration is reached. It is about how long the nutrient has been present in the blood in its biologically active form and how long it has had the chance to exert its effect. This says something about the bioavailability, which is defined as that part of a nutrient that has been absorbed into the body and is available for use in certain bodily processes. \r\u003cbr\u003e\r\u003cbr\u003e Due to the high bioavailability, a low effective dosage of Curcumin-SLCP™ is sufficient. And because it remains active as curcumin in the body for a long time, a single daily dosage is enough. This has many advantages for user-friendliness. Not everyone can tolerate high dosages of curcumin well, and it is also easier to only have to think about taking a supplement once a day.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eComposition\u003c\/b\u003e\u003cbr\u003e\u003ctable border=\"1\" cellpadding=\"1\" cellspacing=\"1\" style=\"width:400px\"\u003e\r\n\t\u003ctbody\u003e\r\n\t\t\u003ctr\u003e\r\n\t\t\t\u003ctd\u003e\u003cstrong\u003eComposition per daily dosage of 1 capsule:\u003c\/strong\u003e\u003c\/td\u003e\r\n\t\t\t\u003ctd\u003e \u003c\/td\u003e\r\n\t\t\u003c\/tr\u003e\r\n\t\t\u003ctr\u003e\r\n\t\t\t\u003ctd\u003eCurcumin-SLCP™ (Longvida®)\u003c\/td\u003e\r\n\t\t\t\u003ctd\u003e400 mg\u003c\/td\u003e\r\n\t\t\u003c\/tr\u003e\r\n\t\t\u003ctr\u003e\r\n\t\t\t\u003ctd\u003eOf which curcumin\u003c\/td\u003e\r\n\t\t\t\u003ctd\u003e80 mg\u003c\/td\u003e\r\n\t\t\u003c\/tr\u003e\r\n\t\u003c\/tbody\u003e\r\n\u003c\/table\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eIngredients\u003c\/b\u003e\u003cbr\u003eStabilizers (stearic acid, phosphatidylcholine [from SOY lecithin]), hydroxypropylmethylcellulose (plant capsule), curcumin (extract from Curcuma longa), rice flour (Oryza sativa), maltodextrin, anti-caking agents (silicon dioxide, magnesium salts of fatty acids), antioxidant (ascorbyl palmitate)\u003cbr\u003e\u003cbr\u003e\u003cb\u003eUsage\u003c\/b\u003e\u003cbr\u003eTake 1 capsule per day with a meal and water. Stick to the recommended dosage.\r\u003cbr\u003eSuitable for vegetarians and vegans.\r\u003cbr\u003e\r\u003cbr\u003eNote:\r\u003cbr\u003eMay affect the action of Tamoxifen and Sulfasalazine. Consult your doctor or pharmacist.\r\u003cbr\u003eDo not use in case of bile duct disorders and existing liver problems. Turmeric can cause liver problems in rare cases. \r\u003cbr\u003eConsult your doctor in case of jaundice and other unusual complaints.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eStorage instructions\u003c\/b\u003e\u003cbr\u003eStore in a dry and closed place at room temperature.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eManufacturer \/ Distributor\u003c\/b\u003e\u003cbr\u003eVitals dietary supplements BV, \nAntwoordnummer 894, \n1500 VB Zaandam\u003cbr\u003e\u003cbr\u003eThis product is a dietary supplement.\u003cbr\u003e\u003cbr\u003eDo not exceed the recommended dosage.\u003cbr\u003e\u003cbr\u003eA varied, balanced diet and a healthy lifestyle are important. A dietary supplement is not a substitute for a varied diet.\u003cbr\u003e\u003cbr\u003eKeep out of reach of young children.\u003cbr\u003e\u003cbr\u003eStore in a dry, closed place at room temperature, unless otherwise advised on the label.\u003cbr\u003e\u003cbr\u003eConsult a specialist before using supplements in case of pregnancy, lactation, medication use, and illness.","brand":"Vitals","offers":[{"title":"60.00 Capsules","offer_id":58200754291033,"sku":"903467","price":39.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0888\/2343\/1513\/files\/8716717002962_A1N1.png?v=1780487578","url":"https:\/\/www.biolovers.nl\/en\/products\/vitals-curcumin-slcp-60-capsules","provider":"Biolovers","version":"1.0","type":"link"}